Date of Award
6-2002
Document Type
Open Access
Degree Name
Bachelor of Science
Department
Chemistry
Language
English
Abstract
Previous work has shown that chlorotitanium enolates of methylmethoxy acetate add to aryl aldimines in a stereoselective fashion. Aryl aldimines are non-enolizable, which contributes to their ability to add to the enolates. Previous attempts to add the enolates to enolizable alkyl aldimines were unsuccessful. By using a multi-component process in which the aldimine is synthesized in-situ, we have expanded the scope of this chemistry to the enolizable alkyl aldimines. Furthermore, the multi-component process has proven to be stereoselective for the anti-adduct.
Recommended Citation
Joffe, Avrum L., "A stereoselective multi-component synthesis of alpha-oxy-beta-substituted-beta-amino esters" (2002). Honors Theses. 2082.
https://digitalworks.union.edu/theses/2082
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