Date of Award
6-1999
Document Type
Open Access
Degree Name
Bachelor of Science
Department
Chemistry
Language
English
Abstract
The regulation of actin stress fibers (SF) are linked to the stability of microtubule (M1) structures. The exact method of interaction is not understood. To study the interaction, live cells containing fluorescent α-actinin were observed and treated with MT perturbing drugs as well as ATP-depletion. These treatments affect the stability of the microtubules and stress fibers respectively. A plasmid coding for fluorescent tubulin was also inserted into these cells to aid in observing both the MTs and SFs simultaneously. The observation relies on fluorescent microscopy and digital imaging. By observing the changes in the MTs and SFs in live cells, it is hoped that the mechanism of their interaction will be shown.
Recommended Citation
Kelmanovich, Daniel Jason, "The dynamic interactions of actin stress fibers and microtubutes" (1999). Honors Theses. 2069.
https://digitalworks.union.edu/theses/2069
Rights Statement
