Date of Award

6-2005

Document Type

Union College Only

Degree Name

Bachelor of Science

Department

Chemistry

Language

English

Abstract

Protein-ligand interactions are often at the center of cellular regulatory processes. The Enabled/ vasodilator Stimulated Phosphoprotein Homology 1 (EVH1) domain of the Enabled/ Vasodilator Stimulated Phosphoprotein (Ena/VASP) protein family has been linked to the regulation of the actin cytoskeleton through multiple protein-protein interactions via the recognition of polyproline amino acid sequences. Here, we examine the structural and physicochemical features of the EVH1 domain in an effort to design high affinity peptide-peptoid hybrid ligands that compete with EVH1's natural binding partners. & The unique photophysical properties of aryl, tridentate complexes of platinum have recently led to a surge in ligand design efforts. Here, we outline a facile synthetic route to platinum ligands with N^C^C and O^C^C binding modes, two classes of compounds that have yet to be investigated.

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