Date of Award
Union College Only
Bachelor of Science
The amides of N-methoxy-N-methylamine or "Weinreb amide" have earned an important role in synthetic chemistry as both a protective group and as synthetic intermediates. We have discovered that the Weinreb amide of acetic acid, N-methoxy-N-methylacetamide adds to aldehydes to afford classic aldol products in good to excellent yields. The scope of this novel aldol reaction will be discussed.
Leyhane, Andrew J., "Weinreb amides : novel titanium enolate reagents" (2002). Honors Theses. 2083.