Date of Award
Union College Only
Bachelor of Science
The separation by capillary zone electrophoresis (CZE) of the chiral narcotic propoxyphene is the goal of this work. A three-way collaboration between our research group, Professor lsiah Warner (LSU), and the New York State Forensic Investigation Center is underway, with the goal of separating controlled substances and developing techniques that the Forensic Center can apply in it& investigations. Earlier studies by Warner's group have shown that using polymerized N-undecylenyl-L-amino acid and peptide derivatives as pseudo-stationary phases in CZE has resulted in the separation of chiral molecules. Our separations were attempted by combining the drug samples with polymerized N-undecylenyl-L-amino acid and peptide surfactants. Successful chiral separation of (+/-) I, I' bi-2-naphthol was achieved using polymerized N-undecylenyl-L-valine. The bulk of the studies involved the attempted chiral separation of d/1- propoxyphene using this and other polymerized micelles. Preliminary studies using and β-cyclodextrins as chiral selectors show partial separation of the d/1-propoxyphene enantiomers.
Jakubowski, Jennifer A., "Forensic applications of capillary electrophoresis" (2000). Honors Theses. 2074.