Date of Award
Bachelor of Science
A mild and versatile synthesis of a-oxy-6-amino esters has been performed by condensation of the chlorotitanium enolates of methyl methoxyacetate with aldimines. The imine-aldol addition occurs in excellent yields without Lewis acid activation of the imine. All aryl imines examined show good to excellent diastereoselection for the anti isomers.
Barkin, Julia Leigh, "Diastereoselection in titanium enolate addition to aldmines" (2000). Honors Theses. 2072.