Date of Award
Bachelor of Science
The synthesis of drugs and natural products in enartiomerically pure form is a growing area of research. Our laboratory is currently working on synthetic methodologies that would facilitate the production of compounds in such a form. The approach we are taking is to use chiral silanes as templates for the stereochemical control of organic reactions. In order to do this, however, we must first synthesize these silanes enantiomerically pure. This project focuses on the synthesis of chiral silanes by selective oxidation of prochiral dihydrosilanes to yield directly, or by further transformations, halohydrosilanes. These halohydrosilanes can in turn, be used as precursors in the chiral synthesis of a variety of chiral silanes by the nucleophilic displacement of halide in SN2 fashion.
Gansle, Paul B. Jr., "The Selective Oxidation of Dihydrosilanes" (1993). Honors Theses. 2038.