Date of Award

6-1968

Document Type

Union College Only

Degree Name

Bachelor of Science

Department

Chemistry

Language

English

Abstract

This research project was undertaken in order to determine the applicability of ultraviolet absorption spectroscopy as a means of studying the carbamate reaction of carbon dioxide with glycine or diglycine. These compounds are thought to model the physiological substrate hemoglobin. Where for glycine R = -CH2- and for diglycine R = -CH2-CO-NH- CH2-. The reaction involves only the non-ionized alpha-amino group of the conjugate base species. It is therefore necessary that the reaction be run in a moderately basic medium, but at pHs not greater than ten. The ultraviolet absorption spectra for the conjugate acid, zwitter-ion, and conjugate base of glycine and diglycine have been determined, with specific limitations, in aqueous solutions. The carbamate reaction has been subjected to the same conditions as imposed by Stadie and O’Brien (44). The presence of carbon dioxide in aqueous solutions of glycine and diglycine appear only to affect their ultra-violet absorption spectra through a pH dependent mechanism. The ultraviolet absorption studies give no evidence of a direct chemical reaction of carbon dioxide with the alpha-amino groups of the conjugate base of either compound.

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