Date of Award
Union College Only
Bachelor of Science
Osteoclasts, FSH, Osteoporosis, RAW264.7, Bone Health, Menopause, Estrogen, Sex Hormones
Osteoporosis can be a devastating illness which causes large losses of both monetarily and in terms of quality of life. Interestingly, two of the major risk factors for developing osteoporosis are age and gender as osteoporosis commonly affects postmenopausal women. For decades, osteoporosis was thought be driven by estrogen loss following menopause, however recent research has shown that FSH, the upstream endocrine regulator of estrogen, drives the development of this disease. Using RAW 264.7 cells, we tested the changes that FSH induces in preosteoclastic cells. We noted significant changes in kinase activation and ROS production in an FSH-dependant manner. Similarly, FSH induced gross morphological changes in this cell line.
Leamon, Annie and Cohen, Brian, "FSH Responsiveness by a Murine Preosteoclastic Cell line" (2018). Honors Theses. 1593.