Date of Award
Union College Only
Bachelor of Science
embryo, hormone, serum, pregnancy, fertilization, stimulation
Anti-Müllerian Hormone (AMH) is a TGF-β protein essential to sexual differentiation during embryogenesis of the fetal male. Although AMH is best known for inducing apoptosis in target tissue, recent studies suggest that this hormone positively regulates the viability of pre-ovulatory oocytes by preventing atresia and over-selection by follicle-stimulating hormone (FSH). This study has been a retrospective analysis in which serum AMH levels of 171 female In-Vitro Fertilization (IVF) patients treated at Albany IVF & Infertility between 2007 and 2009 were correlated with factors describing oocyte quality and pregnancy success. As AMH is a classic inducer of apoptosis, yet reduces oocyte sensitivity to excessive FSH stimulation, it was hypothesized that median serum AMH levels would correspond with good quality oocytes and pregnancy success. Results suggest that AMH levels in the 75th-100th percentile are associated with a greater number of retrieved oocytes after ovulation induction, successful fertilization and embryo cleavage, good quality blastocyst formation, lower serum FSH values and administered gonadotropin, as well as successful ongoing pregnancy. Overall, this study reveals AMH to be a mediator of oocyte quality and a key marker that may predict patient response to assisted reproductive technology (ART) procedures. Establishing AMH as a routine and relevant measurement in infertility clinics may help to alleviate the fiscally and emotionally taxing nature of ART for patients and practitioners.
St. Hilaire, Genevieve, "Quality versus quantity : serum AMH levels predict oocyte viability and pregnancy success in female IVF patients" (2010). Honors Theses. 1229.